BCR-ABL Minor PCR Detection Kit

Zena Max – AMD BCR/ABL QPCR Kits

Overview.

BCR-ABL is a fusion gene abnormality found on chromosome 22 of leukaemia cancer cells, which is the cause of chronic myelogenous leukaemia (CML) and some other leukaemias.

The BCR-ABL minor transcript is a fusion gene typically associated with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL). It results from a translocation between chromosomes 9 and 22 [t(9;22)(q34;q11)]. This leads to the production of a 190 kDa (p190) fusion protein, distinct from the p210 protein commonly found in chronic myeloid leukaemia (CML). Detection of the BCR-ABL minor transcript by RT-PCR is crucial for diagnosing Ph+ ALL, guiding targeted therapy (such as with tyrosine kinase inhibitors like imatinib or dasatinib), and monitoring minimal residual disease (MRD). Early and accurate detection significantly impacts prognosis, as Ph+ ALL typically has a more aggressive course but responds well to targeted treatments when identified promptly.

Product Details:

Advanced Molecular Diagnostics Human BCR-ABL Minor PCR Kit

Quality: All AMD kits are manufactured under high-quality standardisation methods and unique precision and sensitive technology studies compared to the most famous and approved commercial Human BCR-ABL diagnostics.

Sensitivity: Advanced Molecular Diagnostics Human BCR-ABL Minor kit is a very sensitive kit which reaches up to 0,01 % BCR/ABL positive cells per “rxn volume 25ul” under our validation methods and devices.

Specificity: The Advanced Molecular Diagnostics Human BCR-ABL kit is specific up to 100% for Human BCR-ABL under our validation methods and devices.

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